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Chemokine Therapeutics Corp. Website: Click Here


Exchange: TSX
 

Market Cap: 34.1 Million

Outstanding Shares: 33.8 Million

52 Low / High : $ 0.95 / $ 1.50

Price May 31, 2005 $ 1.01

CTI Recent Stock Quote and News: Click Here

Information As Of May 31, 2005

 

'The group treated with CTCE-9908 had a dramatic decrease (67%) in the number of visible lung nodules due to the cancer spreading when compared to the untreated group.'

Overview

Chemokine Therapeutics Corp. is a biotechnology company developing drugs in the field of chemokines and cytokines, a family of small, soluble proteins, which signal stem cell transport and growth into mature cells. These stem cells are master primitive cells, capable of producing billions of mature cells necessary for repair and regeneration. The Company’s main focus is to develop synthetic versions of chemokines which may have potential applications to address unmet medical needs in cancer, immune deficiencies, vascular disease, and infectious diseases.

Tackling those diseases that still ail the population is where Chemokine Therapeutics is aiming its efforts. A Delaware-based corporation with offices in Vancouver and Manhattan. Chemokine is busy developing peptide-based drugs to treat cancer, cardiovascular and infectious disease, efforts which bore fruit this month with encouraging results from tests of its immune booster compound on healthy volunteers.

At the Vancouver facility, Chemokine Therapeutics designs and tests hundreds of peptides for possible development as drug candidates. Currently, the company has five lead products with two of these candidates already in human trials; for immune system recovery following chemotherapy and, a novel anti-cancer drug designed to prevent the spread of the disease. Peptides based drugs produced by the Company's technology have very high affinity for natural chemokine receptors, a high degree of specificity, and long duration of activity. Natural chemokines are well known to play a key role in the recruitment and trafficking of a variety of infection-fighting immune cells. In addition recent research has shown that chemokines may play an important role in cancer, cardiovascular disease and viral infections.

Chemokine Therapeutics' competitive advantage lies in its ability to design synthetic versions of natural chemokines that play an important role in disease prevention and other physiological disorders. Its peptide therapies are based on compounds containing two or more amino acids linked by the carboxyl group of one amino acid to the amino group of another. The Company has already attracted research collaborations with pharmaceutical giant, Procter and Gamble Pharmaceuticals as well as prestigious institutions such as the National Cancer Institute, Memorial Sloan Kettering Institute in New York and the Walther Cancer Institute in Indiana.

Companies with leading edge technologies present attractive risk/reward opportunities for investors. Chemokine Therapeutics represents only a handful of biotechnology companies with technology that has the potential to exploit chemokine biology, in the war against infectious disease, cancer, cardiovascular disease. But going full-bore with this research entails big capital inflows, which biotechnology companies share, in part, by licensing drugs to larger pharmaceutical companies. Small cap investors willing and able to share some of the risk of that research with the company benefit from helping to fund clinical trials through to the licensing or acquisition stage. A future special report will investigate some of the history of this dynamic company, its recent successes in developing a cancer treatment, along with some of the volatility its stock price has endured of late. Also in this upcoming special report, investors should better understand this new technology and its successes and perhaps be stimulated by what they read to consider backing this exciting new work.

 

Chemokine Therapeutics has two lead product candidates in clinical trials:

  • CTCE-0214 for immune system recovery.
  • CTCE-9908 for preventing the spread and continued growth of cancer cells.
     

 


Investment Highlights
  • Completion of a single dose Phase I clinical trial in healthy volunteers for our lead compound CTCE-0214. Results of the Phase I clinical trial have just been released.
  • A study conducted by the National Cancer Institute (NCI), demonstrated that CTCE-9908 decreased the spread of cancer to the lung in mice that had osteosarcoma by 67%. These results were announced at the American Association for Cancer Research 2005 Annual Meeting on April 17, 2005.
  • The closing of a CDN$2.4 million over-allotment option to bring the total proceeds raised under the company's initial public offering to CDN$18.4 million.
  • Completion of Phase I study of anti-cancer drug CTCE-9908 in healthy adults which did not reveal any significant toxicity.
  • In preclinical models CTCE-9908 has demonstrated the prevention of cancer spreading from its primary origins.
  • The pharmaceutical market in general has grown at rates above GDP growth. According to IMS World Review 2004, audited pharmaceuticals sales grew at 9% to US$466.3 billion in 2003.
  • World-wide sales of neutropenia treatments in 2003 the companyre approximately US$3 billion and are projected to increase to over US$4.5 billion by 2008 according to Business Communications Company, Inc.

What are Natural Chemokine
 

  • Chemokines are a recently discovered family of small, soluble proteins, structurally-related to cytokines. They assume a range of important functions in the human body, mainly in relation to the immune system. Among other functions, chemokines are responsible for blood cell formation through stem cell growth and differentiation. In addition, chemokines participate in white blood cell mobilization and in the initiation of immune responses. They are produced and released by a wide variety of cell types.
  • In addition to their designated natural functions, chemokines have been found to play an important role in the physiological processes of a variety of prominent and critical diseases. There is a growing focus in the scientific community on chemokine involvement in cancer, both at the level of blood vessel generation and metastasis, in viral infections such as HIV and in autoimmune diseases, as evidenced by studies in an increasing number of research publications and articles.

Products
 

CTCE 9908

 
When a cancer spreads from its original site to another area of the body, it is termed metastatic cancer. CTCE-9908, based on the companys pre-clinincal studies has the potential to reduce or delay the progression of cancers.
 

 

Market Need For CTCE-9908

As a potential anti-metastasis cancer therapy, we believe that CTCE-9908 is unique and has the potential to address a large and growing cancer market. Cancer is a major health care problem as approximately 23% of all deaths in the U.S. in 2001 were caused by cancer according to the National Cancer Institute. The National Cancer Institute estimates that there were 1,368,030 new cases of cancer in 2004 in the U.S., including 230,110 prostate cancers; 217,440 female breast cancers; 173,770 lung cancers; and 146,940 cancers of the colon/rectum. In addition, the risk of being diagnosed over one’s lifetime with cancer is approximately 46% of U.S. males and 38% of U.S. females according to the National Cancer Institute.
 

According to the American Cancer Society, about one-third of patients with cancer, excluding nonmelanoma skin cancers, have metastases that are detected at the time their cancer is first diagnosed. Another third of patients have metastases that are too small to be detected by usual diagnostic tests. These micrometastases, however, will eventually grow into clinically significant metastases if the patient receives no treatment or local treatment of the primary tumour only.
 

 

CTCE-0214
CTCE- 0214 has the potential to restore infection-fighting white blood cells and platelets to prevent bleeding. Cancer patients may be able to receive aggressive chemotherapy in combination with CTCE-0214 and minimize delays caused by infection, low white blood cell counts and/or low platelet counts. CTCE-0214 also has the potential to be used in stem cell mobilization indications and offers potential improvement compared to the currently available therapies. The results of the companys pre-clinical studies show that CTCE-0214 has a rapid mode of action, enabling the required increase of the stem cells, white blood cells and platelets to recover rapidly. Currently available treatments require more time.
 

The company has disclosed in pre-clinical studies that CTCE-0214;
 

  • Increased the number of infection-fighting neutrophils in the blood stream by approximately 710% over the number of neutrophils in the blood stream of the control.
  • Increased the number of platelets in the blood stream by approximately 260% over the number of platelets in the blood stream of the control;
     
  • Increased the number of stem cells in the blood stream by approximately 340% over the number of stem cells in the blood stream of the control.

World-wide sales of neutropenia treatments in 2003 were approximately US$3 billion and are projected to increase to over US$4.5 billion by 2008 according to the company.


 

 
Technology
The technology of Chemokine Therapeutics is to design peptide analogs and peptidomimetics to mimic or to block the function of chemokines known as chemokine agonists and antagonists, respectively.

Chemokine Therapeutics has a proprietary technology that enables the Company to produce a smaller version of all types of chemokines by chemical synthesis in a speedy manner. The products of this technology are extremely effective in replacing the chemokines with low toxicity profile. The chemokine antagonists produced by the Company's technology have very high affinity for chemokine receptors, a high degree of specificity, and long duration of activity.

The graph below demonstrates the 3-D structure of three chemokines in solution and the sites for replacement via rationally designed small peptide analogs or peptidomimetics.
 

Using its technology the Company has already produced over 1000 chemokine mimetics and antagonists


 


Collaboration
 
  • Entered into a research collaboration with Procter & Gamble Pharmaceuticals, Inc. to explore the potential of chemokines for vascular and cardiovascular diseases.
  • Chemokine Therapeutics Corp. has the potential to recieve predefined milestone and royalty payments upon P&GP's execution of an option to license and develop a compound for commercialization following the conclusion of the research program.
 

 
 

• Chemokine Therapeutics to Present at Rodman & Renshaw Techvest 2nd Annual Global Healthcare Conference (Mon, May 2)
 

• Chemokine Therapeutics' Cancer Compound Highlighted at Major Cancer Conference (Mon Apr. 18)

• Chemokine Therapeutics reports 67% decrease in metastatic nodules with anti-cancer compound (Wed, Mar. 16)
 


Management Team

Hassan Salari, PhD
Chairman, President, & CEO

David L. Karp, CFA, MBA, P.Eng
CFO

Walter Korz, HCA
VP of Drug Development.

Ian Harper, BSc
Director Investor Relations & Corporate Development


Contacts

Vancouver Office:

6190 Agronomy Road
Suite 405
Vancouver, British Columbia,V6T 1Z3
Canada

Telephone: 604.822.0301
Fax: 604.822.0302


SEDAR Filings

CTI filings with SEDAR can be found here. All Fillings are current and the Company is fully reporting.


 

 

 

 

 

FORWARD LOOKING STATEMENTS

This report includes forward-looking statements that reflect Chemokine Therapeutics Corp. current expectations about its future results, performance, prospects and opportunities. Chemokine Therapeutics Corp. has tried to identify these forward-looking statements by using words and phrases such as "may," "will," "expects," "anticipates," "believes," "intends," "estimates," "plan," "should," "typical," "preliminary," "we are confident" or similar expressions. These forward-looking statements are based on information currently available and are subject to a number of risks, uncertainties and other factors that could cause Chemokine Therapeutics Corp.'s actual results, performance, prospects or opportunities to differ materially from those expressed in, or implied by, these forward-looking statements. These risks, uncertainties and other factors include, without limitation, the Company's growth expectations and ongoing funding requirements, and specifically, the Company's growth prospects with scalable customers, and those outlined above. Other risks include the Company's limited operating history, the Company's history of operating losses, consumers' acceptance, the Company's use of licensed technologies, risk of increased competition, the potential need for additional financing, the terms and conditions of any financing that is consummated, the limited trading market for the Company's securities, the possible volatility of the Company's stock price, the concentration of ownership, and the potential fluctuation in the Company's operating results.


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